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Human Phenotype Ontology, a standardized vocabulary of phenotypic abnormalities encountered in human disease. With unmatched depth it enables clinicians to record and analyse data.人类表型本体论(Human Phenotype Ontology,简称HPO)是一个标准化的术语集,用于描述和计算分析人类疾病中发现的表型异常。HPO中的每个术语都描述了一个表型异常,例如心房间隔缺损(Atrial septal defect)。这些术语可用于基因关联研究、药物发现和临床实践等领域。 with extremely accurate computer interpretable ontology terms. Developed by The Monarch Initiative.
AI工具
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Logo maker 一个在线制作 Logo 图标的简易工具,由图标管理器 Iconbuddy 创建,加上超过 20+ 万免费开源的 SVG 图标,毫不费力就能为你的品牌制作独特专业的 Logo 图标,你可以在线自定义 Logo 图标的各种风格样式,比如图标大小、圆角、边框、颜色、渐变等等,最最最重要的是强大开源的图标库任你使用,制作完成即可免费下载使用哦。Design your logo easily! Use our Logo Maker with 200,000 SVG icons. Craft a unique and professional logo for your brand effortlessly.
科研工具
生物科研数据资源
NCBI(National Center for Biotechnology Information)是美国国家生物技术信息中心,是世界上最大的生物信息学数据库和资源提供者之一。NCBI的主要任务是收集、组织和提供生物学和生物医学领域的相关数据和信息,以促进科学研究和医学进展。 NCBI提供了许多重要的数据库,包含生物医学文献的数据库、基因序列数据库,收集了全球范围内的DNA和RNA序列数据。此外,NCBI还提供了许多其他的数据库和工具,用于基因组学、蛋白质学、序列比对、结构预测、基因表达等领域的研究。总之,NCBI是一个重要的生物信息学资源中心,为科学家、医生和研究人员提供了丰富的生物学和生物医学数据,对于推动生命科学研究和医学发展起着重要的作用。
DAVID(Database for Annotation, Visualization, and Integrated Discovery)是一个广泛应用于生物学研究领域的功能注释和生物信息学分析工具。它提供了一个集成的平台,帮助研究人员对基因和蛋白质的功能进行注释和分析。The Database for Annotation, Visualization and Integrated Discovery (DAVID) provides a comprehensive set of functional annotation tools for investigators to understand the biological meaning behind large lists of genes. These tools are powered by the comprehensive DAVID Knowledgebase built upon the DAVID Gene concept which pulls together multiple sources of functional annotations.
针对肺癌样本的分析。lung cancer, clinical database, online analysis, online tool, survival analysis, meta-analysis, comparison analysis, co-expression analysis, patient database, patient data, curated database, differential gene expression between tumor and normal, differential gene expression between male and female, Compare gene expression
KM-plotter是一个在线生存分析工具,能够评估所有基因(mRNA、miRNA、蛋白质和DNA)表达与21种肿瘤类型中35,000多个样本的生存率之间的相关性。它应用了Cox比例风险回归和假发现率(FDR)的计算方法,每天进行18,000次分析,是全球范围内用于发现和验证生存生物标志物的参考资源。Our aim was to develop an online Kaplan-Meier plotter which can be used to assess the effect of the genes on breast cancer prognosis.
The miRNA Enrichment Analysis and Annotation Tool (miEAA) facilitates the functional analysis of sets of miRNAs. With the increase in the amount of data regarding miRNAs, there is also an increase in the need for tools to help analyzing them. MiEAA is one of the tools in this regard. It is based on GeneTrail, which is an enrichment analysis tool for gene sets. In contrast to GeneTrail, miEAA is tailored for miRNA precursors and mature miRNAs of multiple frequently investigated species, for example human, mice, or rat.
A large, publicly available critical care database。MIMIC(Medical Information Mart for Intensive Care)数据库是一个由美国麻省理工学院计算生理学实验室、贝斯以色列女狄肯斯医疗中心以及飞利浦医疗共同发布的开放的重症监护医学信息数据库。该数据库于2003年在美国国立卫生研究院的资助下建立,并且记录了从2001年至2019年间贝斯以色列女狄肯斯医疗中心重症监护病房患者的相关数据。MIMIC数据库包含大量患者样本,具有较长的追踪时间和多样性,能够提供全面的临床信息和高频率的生命体征数据点。它不仅包括人口统计学信息(如性别、身高、宗教等),还涵盖了心电信号(ECG)、光电容积脉搏波信号(Pleth)、动脉血压信号等多种多参数智能监测数据。
生信宝库致力于打造专门针对各类生物医药领域相关的软件工具和数据库的整合资源库。 生信宝库旨在服务于生物信息学科发展的同时,为相关领域的研究者提供工具推荐和数据导航,为软件开发者提供分享自己作品的平台。BioTreasury is committed to building an integrated resource library specifically for software tools and databases related to various biomedical fields. Aiming to serve the development of bioinformatics disciplines, BioTreasury provides tool recommendations and data navigation for researchers in different subject and allow software developers to share their works.
临床生信之家是一个专为临床科研工作者设计的生物信息学分析平台,它提供了一个用户友好的界面,使得即使没有编程背景的临床医生也能轻松进行复杂的生物信息学分析。该平台的特色在于它的“零代码”操作,用户可以通过简单的点击操作来完成数据分析,从而大大提高了科研效率 。 平台目前收录了包括TCGA数据库的所有33种肿瘤类型、TARGET数据库的7种儿童/血液肿瘤样本信息、GEO数据库的肿瘤样本及非肿瘤样本信息、CCLE数据库细胞系数据以及ICGC数据库的24种肿瘤样本信息。用户可以根据特定的临床信息、基因突变或表达量高低进行样本筛选,并进行包括预后分析、表达分析、免疫相关性分析、突变分析等在内的多种分析。
Human Phenotype Ontology, a standardized vocabulary of phenotypic abnormalities encountered in human disease. With unmatched depth it enables clinicians to record and analyse data.人类表型本体论(Human Phenotype Ontology,简称HPO)是一个标准化的术语集,用于描述和计算分析人类疾病中发现的表型异常。HPO中的每个术语都描述了一个表型异常,例如心房间隔缺损(Atrial septal defect)。这些术语可用于基因关联研究、药物发现和临床实践等领域。 with extremely accurate computer interpretable ontology terms. Developed by The Monarch Initiative.
CellMiner is a database and query tool designed for the cancer research community to facilitate integration and study of molecular and pharmacological data for the NCI-60 cancerous cell lines. The NCI-60, a panel of 60 diverse human cancer cell lines used by the Developmental Therapeutics Program of the U.S. National Cancer Institute to screen over 100,000 chemical compounds and natural products (since 1990).
REPIC (RNA Epitranscriptome Collection) is a database dedicated to provide a new resource to investigate potential functions and mechanisms of N6-adenosine methylation (m6A) modifications. Currently, The database includes about 700 samples of 50 public studies that were reprocessed by our refined pipeline.
CellMarker:One of the most fundamental questions in biology is which types of cells form different tissues and organs in a functionally coordinated fashion. Larger-scale single cell sequencing and biology experiment studies are now rapidly opening up new ways to track this question by revealing substantial cell markers for distinguishing different cell types in tissues. Here, we developed the CellMarker databases, aiming to provide a comprehensive and accurate resource of cell markers for various cell types in tissues of human and mouse.
DisGeNET is a discovery platform containing one of the largest publicly available collections of genes and variants associated to human diseases.DisGeNET integrates data from expert curated repositories, GWAS catalogues, animal models and the scientific literature. DisGeNET data are homogeneously annotated with controlled vocabularies and community-driven ontologies. Additionally, several original metrics are provided to assist the prioritization of genotype–phenotype relationships.
The Global Burden of Disease (GBD) study provides a comprehensive picture of mortality and disability across countries, time, age, and sex. It quantifies health loss from hundreds of diseases, injuries, and risk factors, so that health systems can be improved and disparities eliminated.
SymMap integrates traditional Chinese medicine (TCM) with modern medicine (MM) through both internal molecular mechanism and external symptom mapping, thus provides massive information on herbs/ingredients, targets, as well as the clinical symptoms and diseases they are used to treat for drug screening efforts.